The newest episode of season 30 will see the Irish star be joined by a bunch of A-listers.
With such a cracking line-up of stars, as usual, we don't know where to start.
Oscar-nominated Dame Kristin Scott Thomas of 'The English Patient' and 'The Horse Whisperer fame is dropping in to chat all about the second season of her hit Apple TV+ series 'Slow Horses'. The spy thriller sees her star opposite Gary Oldman and Olivia Cooke.
'Star Trek' legend and activist George Takei joins in on the fun tonight, and he'll be talking about the West End musical 'George Takei’s Allegiance', which is based on his childhood experience of the Japanese American internment in World War II. The groundbreaking Broadway musical will run for 13 weeks in the new year.
Next on the bill is writer and 'Strictly Come Dancing' host Claudia Winkleman. The presenter is currently promoting her new reality gameshow called 'The Traitors', which sees contestants attempt compete against each-other in order to win the jackpot - but not all of them are playing the game, and some are out to sabotage.
It's nearly Christmas, so Jamie Oliver has come out of the kitchen and onto our screens for some festive hits yet again. The celebrity chef's latest cookbook, 'One: Simple One-Pan Wonders', is out in book stores in case you're stuck for what to get your mother-in-law this Christmas.
Music tonight comes from Swedish folk superstars First Aid Kit, who will perform 'Out of My Head' live in studio.
You can expect all of this as well as plenty more intrepid members of the audience attempting to recount an anecdote from the dreaded red chair before having their lives flash before their eyes at the pull of a lever.